BIOPEP-UWM: Report

ID 346
Name Bitter peptide
sequence
IW
Function:
Bitter taste
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 317.3819 Monoisotopic mass 317.1734
EC50 :
0.00 µM


Bibliographic data:
Authors
Asao M., Iwamura H., Akamatsu M., Fujita T.
Title
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 30, 1873-1879
Year Source
1987 Journal


Additional information:
BIOPEP database of sensory peptides and amino acids


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C

InChI=1S/C17H23N3O3/c1-3-10(2)15(18)16(21)20-14(17(22)23)8-11-9-19-13-7-5-4-6-12(11)13/h4-7,9-10,14-15,19H,3,8,18H2,1-2H3,(H,20,21)(H,22,23)/t10-,14-,15-/m0/s1

InChIKey: BVRPESWOSNFUCJ-LKTVYLICSA-N


Another reference concerning bitterness:

Collantes E. R., Dunn W. J., 1995, Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues. J. Med. Chem., 38, 2705-2713


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP database of bioactive peptides (ID 8807)
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001) according to AHTPDB database; BindingDB database; BIOPEP database of bioactive peptides (ID 7544); ChEMBL database; EROP-Moscow database; SATPdb database
Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to EROP-Moscow database
Neuropeptide BNC210 according to ChemSpider database; EROP-Moscow database; Wikipedia


Database reference:
AHTPDB: ID 1074; 1085; 1444; 1460; 1468; 1859; 2028; 2214; 2779; 2788; 2847; 2882; 3343; 3503; 3567; 3780; 3863; 3961; 4227; 4237; 4255; 4451; 4486; 4649; 4958; 4959; 5155; 6160; 6264; 6272; 6531; 6880

BindingDB: ID 50407421

BIOPEP database of bioactive peptides: ID 7544; 8807

ChEBI: ID 74080

ChEMBL: ID CHEMBL56923

ChemSpider: ID 5382052

EROP-Moscow: ID E01434

OLSVis: ID CHEBI:74080

PubChem: ID 7019084

SATPdb: ID satpdb20183

ZINC: ID ZINC02556614