BIOPEP-UWM: Report

ID 462
Name Bitter peptide
sequence
VA

Function:
Bitter peptide
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 188.2236 Monoisotopic mass 188.1157
EC50 :
168.24 µM



Bibliographic data:
Authors
Asao M., Iwamura H., Akamatsu M., Fujita T.
Title
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 1987, 30, 1873-1879
Year Source
1987 Journal



Additional information:
BIOPEP database of sensory peptides and amino acids


SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)O

InChI=1S/C8H16N2O3/c1-4(2)6(9)7(11)10-5(3)8(12)13/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1

InChIKey: HSRXSKHRSXRCFC-WDSKDSINSA-N


Another reference concerning bitterness:
Collantes E. R., Dunn W. J ., 1995, Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues. J. Med. Chem., 38, 2705-2713


Inhibitor of Tripeptidyl peptidase 2 (TPP 2) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database, the ChEMBL database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides, the BRENDA database, the EROP-Moscow database
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001) according to the AHTPDB database




Database reference:
AHTPDB: ID 3848

BIOPEP database of bioactive peptides: ID 3172

BRENDA: Ligand Val-Ala

ChEBI: ID 75008

ChEMBL: ID CHEMBL55523

ChemSpider: ID 5360762

CompTox: ID DTXSID60426328

EPA DSSTox: ID DTXCID40377162

EROP-Moscow: ID E09235

J-GLOBAL: ID 200907035026970731

Nikkaji: ID J149.658A

PubChem: CID 6992637

SATPdb: ID satpdb14267

ZINC: ID ZINC01578617