BIOPEP-UWM: Report

ID 51
Name bitter peptide
sequence
VF
Function:
(Rcaf) 0.33
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 264.3194 Monoisotopic mass 264.1469
EC50 :
0.00 µM


Bibliographic data:
Authors
Ishibashi N., Sadamori K., Yamamoto O., Kanehisa H., Kouge K., Kikuchi E., Okai H., Fukui S.
Title
Bitterness of phenylalanine- and tyrosine-containing peptides. Agric. Biol. Chem., 51, 3309-3313, 1987
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of sensory peptides and amino acids


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C(C)C

InChI=1S/C14H20N2O3/c1-9(2)12(15)13(17)16-11(14(18)19)8-10-6-4-3-5-7-10/h3-7,9,11-12H,8,15H2,1-2H3,(H,16,17)(H,18,19)/t11-,12-/m0/s1

InChIKey: GJNDXQBALKCYSZ-RYUDHWBXSA-N


Peptide found in hydrolysate of sardine muscle proteins.
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y., 1994, Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245

Peptide found in amaranth protein hydrolysate.
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to AHTPDB database; BIOPEP-UWM database of bioactive peptides (ID 3384); ChEMBL database; EROP-Moscow database (ID E01330); PubChem database
Inhibitor of Calpain 1 (EC 3.4.22.52) (MEROPS ID: C02.001) according to ChEMBL database; PubChem database
Inhibitor of Tripeptidyl peptidase 2 (EC 3.4.14.10) (MEROPS ID S08.090) according to BRENDA database; ChEMBL database; PubChem database
Inhibitor of Neprilysin-2 (EC 3.4.24.B14) (MEROPS ID: M13.008) according to BRENDA database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8917)


Database reference:
AHTPDB: ID 1099; 1196; 1364; 1499; 1905; 1955; 2585; 2777; 3097; 3121; 3156; 3198; 3341; 3786; 4037; 4120; 4211; 4445; 4492; 4667; 4953; 5176; 5456; 5627; 6145; 6177; 6262; 6368; 6878

BindingDB: ID 50142287

BioPepDB: ID biopep01357

BIOPEP-UWM database of bioactive peptides: ID 3384; 8917

BRENDA: Ligand Val-Phe

ChEBI: ID 75016

ChEMBL: ID CHEMBL8486

ChemIdplus: ID 75946-40-6

ChemSpider ID: 5361223

EROP-Moscow: ID E01330; E03690

FeptideDB: ID 3384; 8917

FooDB: ID FDB112136

HMDB: ID HMDB0029134

J-GLOBAL: ID 200907084614108273

Metabolights: ID MTBLC75016

Nikkaji: ID J149.638G

PubChem: ID 6993120

SATPdb: ID satpdb14826

SureChEMBL: ID SCHEMBL7335375

ZINC: ID ZINC000001605725