BIOPEP-UWM: Report

ID 55
Name bitter peptide
sequence
PF
Function:
(Rcaf) 0.03
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 262.3036 Monoisotopic mass 262.1313
EC50 :
0.00 µM


Bibliographic data:
Authors
Ishibashi N., Sadamori K., Yamamoto O., Kanehisa H., Kouge K., Kikuchi E., Okai H., Fukui S.
Title
Bitterness of phenylalanine- and tyrosine-containing peptides. Agric. Biol. Chem., 51, 3309-3313, 1987
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of sensory peptides and amino acids


SMILES: N1[C@H](C(=O)N[C@H](C(=O)O)Cc2ccccc2)CCC1

InChI=1S/C14H18N2O3/c17-13(11-7-4-8-15-11)16-12(14(18)19)9-10-5-2-1-3-6-10/h1-3,5-6,11-12,15H,4,7-9H2,(H,16,17)(H,18,19)/t11-,12-/m0/s1

InChIKey: IWIANZLCJVYEFX-RYUDHWBXSA-N


Another references concerning peptide bitterness:

Asao M., Iwamura H., Akamatsu M., Fujita T., 1987, Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 30, 1873-1879

Collantes E. R., Dunn W. J., 1995, Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues. J. Med. Chem., 38, 2705-2713


Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1; MEROPS ID: M02-001) according to the AHTPDB database
Inhibitor of dipeptidyl-peptidase III (EC 3.4.14.4; MEROPS ID M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9505); the BRENDA database
Inhibitor of dipeptidyl-peptidase IV (EC 3.4.14.5; MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8854); the BRENDA database
Inhibitor of angiotensin-converting enzyme 2 (EC 3.4.17.23; MEROPS ID: M02.006) according to the BRENDA database; the EROP-Moscow database (ID E03992)


Database reference:
AHTPDB: ID 3875

BIOPEP-UWM database of bioactive peptides: ID 8854; 9505

BRENDA: Ligand Pro-Phe

ChEBI: ID 74795

ChEMBL: ID CHEMBL52922

ChemSpider: ID 4894402

EROP-Moscow: ID E03992

J-GLOBAL: ID 200907023710790183

Metabolights: ID MTBLC74795

Nikkaji: ID J120.395I

PubChem: ID 6351946

SATPdb: ID satpdb18871

SureChEMBL: ID SCHEMBL601567

ZINC: ID ZINC000004038394