BIOPEP-UWM: Report

ID 71
Name bitter peptide
sequence
YP
Function:
(Rcaf) 0.05
 
Number of residues
2
Activity code
bi
Activity :
bitter
Chemical mass 278.3030 Monoisotopic mass 278.1262
EC50 :
0.00 µM


Bibliographic data:
Authors
Ishibashi N., Kubo T., Chino M., Fukui H., Shinoda I., Kikuchi E., Okai H., Fukui S.
Title
Taste of proline-containing peptides. Agric. Biol. Chem., 52, 95-98, 1988
Year Source
1988 Journal


Additional information:
BIOPEP database of sensory peptides and amino acids


SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccc(cc1)O

InChI=1S/C14H18N2O4/c15-11(8-9-3-5-10(17)6-4-9)13(18)16-7-1-2-12(16)14(19)20/h3-6,11-12,17H,1-2,7-8,15H2,(H,19,20)/t11-,12-/m0/s1

InChIKey: VNYDHJARLHNEGA-RYUDHWBXSA-N


The peptide is a hemoglobin fragment.
Lantz I., Glämsta E.-L., Tälback L., Nyberg F., 1991, Hemorphins derived from hemoglobin have an inhibitory action on angiotensin-converting enzyme activity. FEBS Lett., 287, 39-41

Peptide found in amaranth protein hydrolysate.
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001) according to AHTPDB database; BindingDB database; BIOPEP database of bioactive peptides (ID 3666); BRENDA database; ChEMBL database; EROP-Moscow database (ID E09272); PubChem database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP database of bioactive peptides (ID 8521); BRENDA database


Database reference:
AHTPDB: ID 1213; 1344; 1349; 1386; 1673; 1706; 2683; 2981; 2985; 3111; 3405; 3551; 3638; 4055; 4130; 4176; 4951; 5574; 5638; 6474

BindingDB: ID 50348856

BIOPEP database of bioactive peptides: ID 3666; 8521

BRENDA: Ligand Tyr-Pro

ChEMBL: ID CHEMBL1807689

ChemSpider: ID 7971403

EROP-Moscow: ID E06297; E09272

PubChem: ID 9795637

ZINC: ID ZINC04899652