BIOPEP-UWM: Report

ID 94
Name bitter peptide
sequence
FGGF

Function:
(Rcaf) 8.3
 
Number of residues
4
Activity code
bi
Activity :
bitter
Chemical mass 426.4646 Monoisotopic mass 426.1897
EC50 :
0.00 µM



Bibliographic data:
Authors
Tamura M., Miyoshi T., Mori N., Kinomura K., Kawaguchi M., Ishibashi N., Okai H.
Title
Mechanism of bitter casting potency of peptides using O-aminoacyl sugars as model compounds. Agric. Biol. Chem., 54, 1401-1409, 1990
Year Source
1990 Journal



Additional information:
BIOPEP database of sensory peptides and amino acids


SMILES: N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1ccccc1

InChI=1S/C22H26N4O5/c23-17(11-15-7-3-1-4-8-15)21(29)25-13-19(27)24-14-20(28)26-18(22(30)31)12-16-9-5-2-6-10-16/h1-10,17-18H,11-14,23H2,(H,24,27)(H,25,29)(H,26,28)(H,30,31)/t17-,18-/m0/s1

InChIKey: NWFLONJLUJYCNS-ROUUACIJSA-N


First reference concerning bitterness:
Asao M., Iwamura H., Akamatsu M., Fujita T., 1987, Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 30, 1873-1879

Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001) according to BRENDA database



Database reference:
BRENDA: Ligand Phe-Gly-Gly-Phe

ChEMBL: ID CHEMBL56945

ChemSpider: ID 23148901

PepBank: ID FGGF