BIOPEP-UWM: Report

ID 137
Name Bitterness suppressing peptide
sequence
GKP
Function:
Predicted ligand of bitternes receptor T2R14 (BitterDB ID: 14)
 
Number of residues
3
Activity code
bis
Activity :
bitterness suppressing
Chemical mass 300.3531 Monoisotopic mass 300.1792
EC50 :
0.00 µM


Bibliographic data:
Authors
Yu Z., Wang Y., Zhao W., Li J., Shuian D., Liu J.
Title
Identification of Oncorhynchus mykiss nebulin-derived peptides as bitter taste receptor TAS2R14 blockers by in silico screening and molecular docking. Food Chem., 368, 130839, 2022
Year Source
2022 Journal


Additional information:
BIOPEP-UWM Virtual database


SMILES: [H][C@@](CCCCN)(NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C13H24N4O4/c14-6-2-1-4-9(16-11(18)8-15)12(19)17-7-3-5-10(17)13(20)21/h9-10H,1-8,14-15H2,(H,16,18)(H,20,21)/t9-,10-/m0/s1

InChIKey=WDEHMRNSGHVNOH-UWVGGRQHSA-N


Bioactivity predicted using molecular docking


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 3506); the ChEMBL database; the EROP-Moscow database; the PlantPepDB database; the PubChem database


Database reference:
AHTPDB: ID 1587, 1663, 2252, 2578, 2852, 3924, 4073, 4797, 5207, 5564, 5589, 5946, 6425, 6863

BindingDB: ID 50049795

BIOPEP-UWM database of bioactive peptides: ID 3506

ChEMBL: ID CHEMBL3322008

ChemSpider: ID 58113011

EROP-Moscow: ID E09244

FeptideDB: ID 3506

PlantPepDB: ID PPepDB_2909

PubChem: CID 53308269

SATPdb: ID satpdb15034

ZINC: ID ZINC000039817963