BIOPEP-UWM: Report

ID 165
Name Acetylcholinesterase inhibitor
sequence
WYRFGYWTW

Function:
Predicted ligand of Acetylcholinesterase (EC 3.1.1.7) (PDB ID: 4BDT)
 
Number of residues
9
Activity code
ache
Activity :
AChE inhibitor
Chemical mass 1364.5030 Monoisotopic mass 1363.6120
EC50 :
0.00 µM



Bibliographic data:
Authors
Tahmasebi E., Dastan D., Ebadi A.
Title
Design, synthesis and biological evaluation of anticholinesterase peptides: fragment-based vs. template-based peptide design. Bioorg. Chem., 105, 104351, 2020
Year Source
2020 Journal



Additional information:
BIOPEP-UWM Virtual database


SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O

InChI=1S/C72H81N15O13/c1-40(88)63(70(98)86-61(71(99)100)35-46-38-79-55-19-10-7-16-51(46)55)87-69(97)60(34-45-37-78-54-18-9-6-15-50(45)54)85-67(95)58(31-42-21-25-47(89)26-22-42)81-62(91)39-80-65(93)57(30-41-12-3-2-4-13-41)84-66(94)56(20-11-29-76-72(74)75)82-68(96)59(32-43-23-27-48(90)28-24-43)83-64(92)52(73)33-44-36-77-53-17-8-5-14-49(44)53/h2-10,12-19,21-28,36-38,40,52,56-61,63,77-79,88-90H,11,20,29-35,39,73H2,1H3,(H,80,93)(H,81,91)(H,82,96)(H,83,92)(H,84,94)(H,85,95)(H,86,98)(H,87,97)(H,99,100)(H4,74,75,76)/t40-,52+,56+,57+,58+,59+,60+,61+,63+/m1/s1

InChIKey=XBQCBEBVKYUQDD-BSWDNLFDSA-N


Bioactivity predicted using molecular docking



Database reference: