BIOPEP-UWM: Report

ID 191
Name Antithrombotic peptide
sequence
FQSEEQQQTEDELQDK

Function:
Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR)
 
Number of residues
16
Activity code
at
Activity :
antithrombotic
Chemical mass 1981.9721 Monoisotopic mass 1980.8518
EC50 :
0.00 µM



Bibliographic data:
Authors
Tu M., Feng L., Wang Z., Qiao M., Shahidi F., Lu W., Du M.
Title
Sequence analysis and molecular docking of antithrombotic peptides from casein hydrolysate by trypsin digestion. J. Funct. Foods, 32, 313–323, 2017
Year Source
2017 Journal



Additional information:
BIOPEP-UWM Virtual database


SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)O

InChI=1S/C81H124N22O36/c1-36(2)31-50(76(133)94-43(15-24-57(87)109)71(128)101-52(34-64(121)122)78(135)98-49(81(138)139)11-7-8-30-82)99-72(129)47(19-28-61(115)116)95-77(134)51(33-63(119)120)100-73(130)48(20-29-62(117)118)97-80(137)65(37(3)105)103-75(132)44(16-25-58(88)110)92-68(125)42(14-23-56(86)108)90-67(124)41(13-22-55(85)107)91-69(126)45(17-26-59(111)112)93-70(127)46(18-27-60(113)114)96-79(136)53(35-104)102-74(131)40(12-21-54(84)106)89-66(123)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104-105H,7-8,11-35,82-83H2,1-3H3,(H2,84,106)(H2,85,107)(H2,86,108)(H2,87,109)(H2,88,110)(H,89,123)(H,90,124)(H,91,126)(H,92,125)(H,93,127)(H,94,133)(H,95,134)(H,96,136)(H,97,137)(H,98,135)(H,99,129)(H,100,130)(H,101,128)(H,102,131)(H,103,132)(H,111,112)(H,113,114)(H,115,116)(H,117,118)(H,119,120)(H,121,122)(H,138,139)/t37-,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51+,52+,53+,65+/m1/s1

InChIKey=ZLAWVRQYPFJYRM-VKRFTZFASA-N


Bioactivity predicted using molecular docking



Database reference:
DFBP: ID DFBPMIBP0006; DFBPANTH0130; DFBPANTH0168; DFBPMUFU0722