BIOPEP-UWM: Report

ID 211
Name Antithrombotic peptide
sequence
VKEAMAPK

Function:
Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR)
 
Number of residues
8
Activity code
at
Activity :
antithrombotic
Chemical mass 873.0703 Monoisotopic mass 872.4774
EC50 :
0.00 µM



Bibliographic data:
Authors
Tu M., Feng L., Wang Z., Qiao M., Shahidi F., Lu W., Du M.
Title
Sequence analysis and molecular docking of antithrombotic peptides from casein hydrolysate by trypsin digestion. J. Funct. Foods, 32, 313–323, 2017
Year Source
2017 Journal



Additional information:
BIOPEP-UWM Virtual database


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O

InChI=1S/C38H68N10O11S/c1-21(2)30(41)36(56)46-24(11-6-8-17-39)34(54)45-25(14-15-29(49)50)32(52)42-22(3)31(51)44-26(16-20-60-5)33(53)43-23(4)37(57)48-19-10-13-28(48)35(55)47-27(38(58)59)12-7-9-18-40/h21-28,30H,6-20,39-41H2,1-5H3,(H,42,52)(H,43,53)(H,44,51)(H,45,54)(H,46,56)(H,47,55)(H,49,50)(H,58,59)/t22-,23-,24-,25-,26-,27-,28-,30-/m0/s1

InChIKey=VOUISVGLJNTLLA-ZUSSBPFISA-N

Bioactivity predicted using molecular docking



Lipoxygenase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 7796)
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9561); the DFBP database




Database reference:
BIOPEP-UWM database of bioactive peptides: ID 7796; 9561

DFBP: DFBPANOX0125; DFBPANTH0153