BIOPEP-UWM: Report

ID 320
Name Predicted osteoanabolic peptide
sequence
HKEMPFPK
Function:
Predicted ligand of Epidermal growth factor receptor (EGFR) (PDB ID: 1IV0)
 
Number of residues
8
Activity code
ost
Activity :
osteoanabolic
Chemical mass 1013.2116 Monoisotopic mass 1012.5148
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang Y., Niu Y., Fu C., Zhu L., Wang H., Yi Y., Xu W., Guo D.
Title
Preparation, identification and screening of anti-osteoporosis milk-derived peptides: Intervention effects in osteoporosis rats. Food Biosci., 62, 105120, 2024
Year Source
2024 Journal


Additional information:
BIOPEP-UWM Virtual database

SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCSC)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O

InChI=1S/C47H72N12O11S/c1-71-24-19-34(55-42(64)33(17-18-39(60)61)54-41(63)32(13-5-7-20-48)53-40(62)31(50)26-30-27-51-28-52-30)45(67)58-22-9-16-38(58)44(66)57-36(25-29-11-3-2-4-12-29)46(68)59-23-10-15-37(59)43(65)56-35(47(69)70)14-6-8-21-49/h2-4,11-12,27-28,31-38H,5-10,13-26,48-50H2,1H3,(H,51,52)(H,53,62)(H,54,63)(H,55,64)(H,56,65)(H,57,66)(H,60,61)(H,69,70)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1

InChIKey=PBQBGPKBTHCYMQ-QSVFAHTRSA-N


Bioactivity predicted using molecular docking


Antibacterial peptide according to the EROP-Moscow database; the MBPDB database
Antithrombotic peptide according to the DFBP database


Database reference:
DFBP: ID DFBPANTH0158

EROP-Moscow: ID E24849

MBPDB: peptide HKEMPFPK