BIOPEP-UWM: Report

ID 333
Name Predicted osteoanabolic peptide
sequence
GPFPIIV
Function:
Predicted ligand of Epidermal growth factor receptor (EGFR) (PDB ID: 1IV0)
 
Number of residues
7
Activity code
ost
Activity :
osteoanabolic
Chemical mass 741.9148 Monoisotopic mass 741.4411
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang Y., Niu Y., Fu C., Zhu L., Wang H., Yi Y., Xu W., Guo D.
Title
Preparation, identification and screening of anti-osteoporosis milk-derived peptides: Intervention effects in osteoporosis rats. Food Biosci., 62, 105120, 2024
Year Source
2024 Journal


Additional information:
BIOPEP-UWM Virtual database

SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O

InChI=1S/C38H59N7O8/c1-7-23(5)31(36(50)43-32(24(6)8-2)35(49)41-30(22(3)4)38(52)53)42-34(48)28-17-13-19-45(28)37(51)26(20-25-14-10-9-11-15-25)40-33(47)27-16-12-18-44(27)29(46)21-39/h9-11,14-15,22-24,26-28,30-32H,7-8,12-13,16-21,39H2,1-6H3,(H,40,47)(H,41,49)(H,42,48)(H,43,50)(H,52,53)/t23-,24-,26-,27-,28-,30-,31-,32-/m0/s1

InChIKey=VBXAFDSUVWHGGB-LWAQOXNASA-N


Bioactivity predicted using molecular docking


Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 8159); the DFBP database

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 460)

Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR) according to the BIOPEP-UWM Virtual database (ID 220); the DFBP database


Database reference:
AHTPDB: ID 1806, 6754

BioPepDB: ID biopep00385

BIOPEP-UWM database of bioactive peptides: ID 8159

BIOPEP-UWM database of sensory peptides and amino acids: ID 460

BIOPEP-UWM Virtual database: ID 220

ChemSpider: ID 9882264

DFBP: ID DFBPACEI0859; DFBPANTH0163; DFBPMUFU0184

EPA DSSTox: ID DTXCID60421717

EROP-Moscow: ID E14527

FeptideDB: ID 8159

J-GLOBAL: ID 200907034717127309

Nikkaji: ID J1.075.678B

PubChem: ID 11707541

SATPdb: ID satpdb12352