BIOPEP-UWM: Report

ID 340
Name Predicted osteoanabolic peptide
sequence
YPVEPF
Function:
Predicted ligand of Epidermal growth factor receptor (EGFR) (PDB ID: 1IV0)
 
Number of residues
6
Activity code
ost
Activity :
osteoanabolic
Chemical mass 750.8358 Monoisotopic mass 750.3576
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang Y., Niu Y., Fu C., Zhu L., Wang H., Yi Y., Xu W., Guo D.
Title
Preparation, identification and screening of anti-osteoporosis milk-derived peptides: Intervention effects in osteoporosis rats. Food Biosci., 62, 105120, 2024
Year Source
2024 Journal


Additional information:
BIOPEP-UWM Virtual database

SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C38H50N6O10/c1-22(2)32(42-34(49)30-11-6-18-43(30)36(51)26(39)20-24-12-14-25(45)15-13-24)35(50)40-27(16-17-31(46)47)37(52)44-19-7-10-29(44)33(48)41-28(38(53)54)21-23-8-4-3-5-9-23/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,48)(H,42,49)(H,46,47)(H,53,54)/t26-,27-,28-,29-,30-,32-/m0/s1

InChIKey: XHQLRBCHRWBONA-RUAREOIKSA-N


Bioactivity predicted using molecular docking


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 9252)
Opioid peptide according to the the BIOPEP-UWM database of bioactive peptides (ID 9852); the EROP-Moscow database; the MBPDB database
Peptide stimulating mucin synthesis according to the BIOPEP-UWM database of bioactive peptides (ID 9851); the MBPDB database
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP-UWM database of bioactive peptides (ID
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10100)


Database reference:
AHTPDB: ID 5530

BioPepDB: ID biopep01609

BIOPEP-UWM database of bioactive peptides: ID 9252, 9851; 9852; 10100

EROP-Moscow: ID E14778

J-GLOBAL: ID 200907083598287727

MBPDB: Peptide YPVEPF

Nikkaji: ID J2.094.154E

PubChem: CID 14389309

SATPdb: ID satpdb17522