BIOPEP-UWM: Report

ID 370
Name Pancreatic lipase inhibitor
sequence
KPWTQPKTNAIP
Function:
Predicted inhibitor of pancreatic lipase (EC 3.4.23.1) (PDB ID: 1ETH)
 
Number of residues
12
Activity code
plip
Activity :
pancreatic lipase inhibitor
Chemical mass 1380.5864 Monoisotopic mass 1379.7538
EC50 :
0.00 µM


Bibliographic data:
Authors
Mudgil P., Ajayi F. F., Alyafei A. S., Yap P.-G., Gan C.-Y., Maqsood S.
Title
Unlocking the hypolipidemic potential of bioactive peptides derived from probiotic fermented cattle, camel, goat, and sheep milk: a comprehensive investigation through in vitro, in silico, and molecular docking studies. Front. Sustain. Food Syst., 8, 1443708, 2024
Year Source
2024 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O

InChI=1S/C64H101N17O17/c1-6-33(2)50(63(96)81-29-15-22-47(81)64(97)98)76-53(86)34(3)71-55(88)44(31-49(69)85)75-60(93)52(36(5)83)77-54(87)41(19-10-12-26-66)72-57(90)46-21-14-28-80(46)62(95)42(23-24-48(68)84)73-59(92)51(35(4)82)78-56(89)43(30-37-32-70-40-18-8-7-16-38(37)40)74-58(91)45-20-13-27-79(45)61(94)39(67)17-9-11-25-65/h7-8,16,18,32-36,39,41-47,50-52,70,82-83H,6,9-15,17,19-31,65-67H2,1-5H3,(H2,68,84)(H2,69,85)(H,71,88)(H,72,90)(H,73,92)(H,74,91)(H,75,93)(H,76,86)(H,77,87)(H,78,89)(H,97,98)/t33-,34-,35+,36+,39-,41-,42-,43-,44-,45-,46-,47-,50-,51-,52-/m0/s1

InChIKey=YHEHZNMDJHXQQT-USAIYBJDSA-N


Activity predicted using molecular docking.


Database reference: