BIOPEP-UWM: Report

ID 558
Name Tyrosinase inhibitor
sequence
GAPGGAGGVGE
Function:
Predicted inhibitor of Tyrosinase (EC 1.14.18.1) (PDB ID: 2Y9X)
 
Number of residues
11
Activity code
tyr
Activity :
tyrosinase inhibitor
Chemical mass 827.8371 Monoisotopic mass 827.3761
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang R., Li Y., Li Y., Zhang H.
Title
Discovering potential anti‑skin‑aging peptides in collagen: computer‑assisted rapid screening and structure–activity relationships. Collagen and Leather, 7, 30, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(C)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C33H53N11O14/c1-16(2)28(31(55)39-15-25(49)42-19(33(57)58)7-8-27(51)52)43-26(50)14-36-22(46)11-37-29(53)17(3)40-24(48)13-35-23(47)12-38-30(54)20-6-5-9-44(20)32(56)18(4)41-21(45)10-34/h16-20,28H,5-15,34H2,1-4H3,(H,35,47)(H,36,46)(H,37,53)(H,38,54)(H,39,55)(H,40,48)(H,41,45)(H,42,49)(H,43,50)(H,51,52)(H,57,58)/t17-,18-,19-,20-,28-/m0/s1

InChIKey=FSMWEBSSRUZDQA-ABASVGCRSA-N


Activity predicted using molecular docking

Predicted inhibitor of pancreatic elastase (EC 3.4.21.36) (PDB ID: 1BRU) according to the BIOPEP-UWM Virtual database
Predicted inhibitor of Microbial collagenase (EC 3.4.24.3) (MEROPS ID: M09.002) (PDB ID: 2Y6I) according to the BIOPEP-UWM Virtual database


Database reference: