BIOPEP-UWM: Report

ID 56
Name Antiviral peptide
sequence
PLW

Function:
Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB ID: 6LU7)
 
Number of residues
3
Activity code
avi
Activity :
antiviral
Chemical mass 414.4968 Monoisotopic mass 414.2260
EC50 :
0.00 µM



Bibliographic data:
Authors
Behzadipour Y., Gholampour M., Pirhadi S., Seradj H., Khoshneviszadeh M., Hemmati S.
Title
Viral 3CLpro as a target for antiviral intervention using milk‑derived bioactive peptides. Int. J. Pept. Res. Therapeut., 27, 2703–2716, 2021
Year Source
2021 Journal



Additional information:
BIOPEP-UWM Virtual database


SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O


InChI=1S/C22H30N4O4/c1-13(2)10-18(25-20(27)17-8-5-9-23-17)21(28)26-19(22(29)30)11-14-12-24-16-7-4-3-6-15(14)16/h3-4,6-7,12-13,17-19,23-24H,5,8-11H2,1-2H3,(H,25,27)(H,26,28)(H,29,30)/t17-,18-,19-/m0/s1

InChIKey=SRBFGSGDNNQABI-FHWLQOOXSA-N

Bioactivity predicted using molecular docking


Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 3531); the ChEMBL database; the EROP-Moscow database



Database reference:
AHTPDB: ID 1177, 1603, 2245, 4388, 5102, 6449

BindingDB: ID BDBM50348864

BioPepDB: ID biopep01069

BIOPEP-UWM database of bioactive peptides: ID 3531

ChEBI: ID 162451

ChEMBL: ID CHEMBL1807681

ChemSpider: ID 26618431

EROP-Moscow: ID E14733

FeptideDB: ID 3531

J-GLOBAL: ID 200907069117859932

MetaNetX: compound Pro-Leu-Trp; ID MNXM1125041

Nikkaji: ID J2.244.245G

PubChem: CID 4320140

SATPdb: ID satpdb17916

SureChEMBL: ID SCHEMBL9653545

ZINC: ID ZINC000039812739