BIOPEP-UWM: Report

ID 562
Name Tyrosinase inhibitor
sequence
NKKHVWFGE
Function:
Predicted inhibitor of Tyrosinase (EC 1.14.18.1) (PDB ID: 2Y9X)
 
Number of residues
9
Activity code
tyr
Activity :
tyrosinase inhibitor
Chemical mass 1144.2788 Monoisotopic mass 1143.5808
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang R., Li Y., Li Y., Zhang H.
Title
Discovering potential anti‑skin‑aging peptides in collagen: computer‑assisted rapid screening and structure–activity relationships. Collagen and Leather, 7, 30, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C54H77N15O13/c1-30(2)46(69-52(79)42(24-33-27-59-29-62-33)67-50(77)38(17-9-11-21-56)65-49(76)37(16-8-10-20-55)64-47(74)35(57)25-43(58)70)53(80)68-41(23-32-26-60-36-15-7-6-14-34(32)36)51(78)66-40(22-31-12-4-3-5-13-31)48(75)61-28-44(71)63-39(54(81)82)18-19-45(72)73/h3-7,12-15,26-27,29-30,35,37-42,46,60H,8-11,16-25,28,55-57H2,1-2H3,(H2,58,70)(H,59,62)(H,61,75)(H,63,71)(H,64,74)(H,65,76)(H,66,78)(H,67,77)(H,68,80)(H,69,79)(H,72,73)(H,81,82)/t35-,37-,38-,39-,40-,41-,42-,46-/m0/s1

InChIKey=ZZLJYVHLQYROAO-QOHRKOJGSA-N


Activity predicted using molecular docking

Predicted inhibitor of pancreatic elastase (EC 3.4.21.36) (PDB ID: 1BRU) according to the BIOPEP-UWM Virtual database
Predicted inhibitor of Microbial collagenase (EC 3.4.24.3) (MEROPS ID: M09.002) (PDB ID: 2Y6I) according to the BIOPEP-UWM Virtual database


Database reference: