BIOPEP-UWM: Report

ID 564
Name Tyrosinase inhibitor
sequence
PGAAGNAGAKGE
Function:
Predicted inhibitor of Tyrosinase (EC 1.14.18.1) (PDB ID: 2Y9X)
 
Number of residues
12
Activity code
tyr
Activity :
tyrosinase inhibitor
Chemical mass 999.0336 Monoisotopic mass 998.4766
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang R., Li Y., Li Y., Zhang H.
Title
Discovering potential anti‑skin‑aging peptides in collagen: computer‑assisted rapid screening and structure–activity relationships. Collagen and Leather, 7, 30, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C40H66N14O16/c1-19(50-35(64)21(3)48-29(57)16-46-37(66)23-9-7-13-43-23)33(62)45-17-31(59)53-26(14-27(42)55)39(68)51-20(2)34(63)44-15-28(56)49-22(4)36(65)54-24(8-5-6-12-41)38(67)47-18-30(58)52-25(40(69)70)10-11-32(60)61/h19-26,43H,5-18,41H2,1-4H3,(H2,42,55)(H,44,63)(H,45,62)(H,46,66)(H,47,67)(H,48,57)(H,49,56)(H,50,64)(H,51,68)(H,52,58)(H,53,59)(H,54,65)(H,60,61)(H,69,70)/t19-,20-,21-,22-,23-,24-,25-,26-/m0/s1

InChIKey=FOIFDVMUCTYJKQ-CAQMSIDYSA-N


Activity predicted using molecular docking

Predicted inhibitor of pancreatic elastase (EC 3.4.21.36) (PDB ID: 1BRU) according to the BIOPEP-UWM Virtual database
Predicted inhibitor of Microbial collagenase (EC 3.4.24.3) (MEROPS ID: M09.002) (PDB ID: 2Y6I) according to the BIOPEP-UWM Virtual database


Database reference: