BIOPEP-UWM: Report

ID 576
Name Hyaluronidase inhibitor
sequence
GYTGLDGR
Function:
Predicted inhibitor of Hyaluronidase (EC 3.2.1.35) (PDB: ID 2PE4)
 
Number of residues
8
Activity code
hyal
Activity :
Hyaluronidase inhibitor
Chemical mass 837.8749 Monoisotopic mass 837.3968
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang R., Li Y., Li Y., Zhang H.
Title
Discovering potential anti‑skin‑aging peptides in collagen: computer‑assisted rapid screening and structure–activity relationships. Collagen and Leather, 7, 30, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

InChI=1S/C35H55N11O13/c1-17(2)11-22(31(55)45-24(13-28(52)53)30(54)40-15-26(50)42-21(34(58)59)5-4-10-39-35(37)38)44-27(51)16-41-33(57)29(18(3)47)46-32(56)23(43-25(49)14-36)12-19-6-8-20(48)9-7-19/h6-9,17-18,21-24,29,47-48H,4-5,10-16,36H2,1-3H3,(H,40,54)(H,41,57)(H,42,50)(H,43,49)(H,44,51)(H,45,55)(H,46,56)(H,52,53)(H,58,59)(H4,37,38,39)/t18-,21+,22+,23+,24+,29+/m1/s1

InChIKey=UCBSULWZCYSIQC-XHOOGHNISA-N


Activity predicted using molecular docking

Predicted inhibitor of pancreatic elastase (EC 3.4.21.36) (PDB ID: 1BRU) according to the BIOPEP-UWM Virtual database
Predicted inhibitor of Microbial collagenase (EC 3.4.24.3) (MEROPS ID: M09.002) (PDB ID: 2Y6I) according to the BIOPEP-UWM Virtual database
Predicted inhibitor of Tyrosinase (EC 1.14.18.1) (PDB ID: 2Y9X) according to the BIOPEP-UWM Virtual database


Database reference: