BIOPEP-UWM: Report

ID 663
Name Matrix metalloproteinase-1 inhibitor
sequence
PGAAGLKGDR
Function:
Predicted inhibitor of Matrix metalloproteinase-1 (EC 3.4.24.80) (MEROPS ID: M10.014) (PDB: ID 1HFC)
 
Number of residues
10
Activity code
mmp1
Activity :
matrix metalloproteinase-1 inhibitor
Chemical mass 941.0405 Monoisotopic mass 940.5075
EC50 :
0.00 µM


Bibliographic data:
Authors
Zhang R., Li Y., Li Y., Zhang H.
Title
Discovering potential anti‑skin‑aging peptides in collagen: computer‑assisted rapid screening and structure–activity relationships. Collagen and Leather, 7, 30, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM Virtual database


SMILES: N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

InChI=1S/C39H68N14O13/c1-20(2)15-26(50-29(55)18-45-32(59)21(3)49-33(60)22(4)48-28(54)17-46-34(61)23-10-7-13-43-23)36(63)52-24(9-5-6-12-40)35(62)47-19-30(56)51-27(16-31(57)58)37(64)53-25(38(65)66)11-8-14-44-39(41)42/h20-27,43H,5-19,40H2,1-4H3,(H,45,59)(H,46,61)(H,47,62)(H,48,54)(H,49,60)(H,50,55)(H,51,56)(H,52,63)(H,53,64)(H,57,58)(H,65,66)(H4,41,42,44)/t21-,22-,23-,24-,25-,26-,27-/m0/s1

InChIKey=WUZRDDJNEYWGHP-DUJSLOSMSA-N


Inhibitor of Microbial collagenase (EC 3.4.24.3; MEROPS ID: M09.002) according to the BIOPEP-UWM database of bioactive peptides (ID 11283)
Inhibitor of Tyrosinase (EC 1.14.18.1) according to the BIOPEP-UWM database of bioactive peptides (ID 11290)
Inhibitor of Hyaluronidase (EC 3.2.1.35) according to the BIOPEP-UWM database of bioactive peptides (11299)
Inhibitor of Pancreatic elastase (EC 3.4.21.36) according to the BIOPEP-UWM database of bioactive peptides (11304)


Activity predicted using molecular docking


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 11283; 11290; 11299; 11304