BIOPEP-UWM: Report
| ID | 671 |
| Name | Umami peptide |
| sequence |
| Function: | |||
| Predicted ligand of umami taste receptor T1R1 (AlphaFold model AF-Q7RTX1-F1) and T1R3 (AlphaFold model AF-Q7RTX0-F1) | |||
| Number of residues | 2 |
Activity code | um |
| Activity : | umami |
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| Chemical mass | 204.1801 | Monoisotopic mass | 204.0743 | |
| EC50 : | 0.00 µM |
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| Bibliographic data: | |
| Authors | |
| Im S. T., Kim Y., Kim M. J., Kang M.-C. | |
| Title | |
| Structural and functional characterization of short acidic dipeptides interacting with the human T1R1/T1R3 receptor. Int. J. Pept. Res. Therapeut., 32, 67, 2026 | |
| Year | Source |
| 2026 | Journal |
| Additional information: |
| BIOPEP-UWM Virtual database SMILES: NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C7H12N2O5/c8-3-5(10)9-4(7(13)14)1-2-6(11)12/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14)/t4-/m0/s1 InChIKey=IEFJWDNGDZAYNZ-BYPYZUCNSA-N Interaction with umami receptors predicted using molecular docking Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 7615); the ChEMBL database; the EROP-Moscow database; the PubChem database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8781) Inhibitor of citrulline uptake in yeasts according to the ChEMBL database; the PubChem database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (D 9487); the BRENDA database Inhibitor of Glutamate carboxypeptidase (EC 3.4.17.11) (MEROPS ID: M20.001) according to the BIOPEP-UWM database of bioactive peptides (ID 10623); the BRENDA database Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) (MEROPS ID: M28.010) according to the BIOPEP-UWM database of bioactive peptides (ID 10654); the BRENDA database Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001) ) according to the BIOPEP-UWM database of bioactive peptides (ID 10911) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 137) |
| Database reference: |
| AHTPDB: ID 1474; 3043; 3247; 3425; 3814; 3917; 4409; 4520; 4689; 6601 BindingDB: ID 50188529 BioPepDB: ID biopep00330 BIOPEP-UWM database of bioactive peptides: ID 7615; 8781; 9487; 10623; 10654; 10911 BIOPEP-UWM database of sensory peptides and amino acids: ID 137 BRENDA: Ligand Gly-Glu CAS: Registry No 7412-78-4 ChEBI: ID 73801 ChEMBL: ID CHEMBL314532 ChemIDplus: ID 007412784 ChemSpider ID: 89688 DFBP: ID DFBPACEI1631 ECHA: ID 231-019-4 EPA CompTox: ID DTXSID401314278 EROP-Moscow: ID E10387 J-GLOBAL: ID 200907069620514802 MeSH: Terms Gly-Glu; N-glycylglutamic acid Metabolights: ID MTBLC73801 Nikkaji：ID J149.621B PlantPepDB: ID PPepDB_53 PubChem: CID 99278 SATPdb: ID satpdb13269 SureChEMBL: ID SCHEMBL709721 UniChem: ID 314736 Wikidata: ID Q27144115 ZINC: ID ZINC02567986 |