BIOPEP-UWM: Peptide Data
ID
Name
Sequence
EILDVPST
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Function Information
The authors prepared three peptides derived from the type III connecting segment domain (IIICS) of fibronectin: EILDV, EILDVPST, REDV, and a laminin-related peptide YIGSR. Each peptide inhibited the experimental tumor metastasis of B16-BL6 melanoma, while EILDV had the strongest effect. The peptides conjugated with poly(ethylene glycol) (PEG) were more effective than the unmodified peptides in molar ratio terms. A mixture composed of PEG hybrids with EILDV, REDV and YIGSR significantly inhibited tumor metastasis.
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