BIOPEP-UWM: Peptide Data
ID
Name
Sequence
CYFQNCPRGG
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)O InChI=1S/C48H69N15O14S2/c49-28(23-78)40(70)59-31(19-26-10-12-27(64)13-11-26)44(74)60-32(18-25-6-2-1-3-7-25)43(73)57-30(14-15-36(50)65)42(72)61-33(20-37(51)66)45(75)62-34(24-79)47(77)63-17-5-9-35(63)46(76)58-29(8-4-16-54-48(52)53)41(71)56-21-38(67)55-22-39(68)69/h1-3,6-7,10-13,28-35,64,78-79H,4-5,8-9,14-24,49H2,(H2,50,65)(H2,51,66)(H,55,67)(H,56,71)(H,57,73)(H,58,76)(H,59,70)(H,60,74)(H,61,72)(H,62,75)(H,68,69)(H4,52,53,54)/t28-,29-,30-,31-,32-,33-,34-,35-/m0/s1 InChIKey: CPUMTTGYTMPHJF-DZCXQCEKSA-N The active form is C-terminal amide group instead of C-terminal glycine residue. Peptide is the precursor of vasopressin (ID 2572 in BIOPEP-UWM database of bioactive peptides). Reviews concerning C-terminal amidation of peptides: Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115 Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456
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