BIOPEP-UWM: Peptide Data
ID
Name
Sequence
TNRNFLRFG
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O InChI=1S/C50H77N17O13/c1-26(2)20-32(44(76)61-30(16-10-18-58-49(54)55)42(74)64-33(41(73)60-25-39(71)72)21-28-12-6-4-7-13-28)63-45(77)34(22-29-14-8-5-9-15-29)65-47(79)35(23-37(51)69)66-43(75)31(17-11-19-59-50(56)57)62-46(78)36(24-38(52)70)67-48(80)40(53)27(3)68/h4-9,12-15,26-27,30-36,40,68H,10-11,16-25,53H2,1-3H3,(H2,51,69)(H2,52,70)(H,60,73)(H,61,76)(H,62,78)(H,63,77)(H,64,74)(H,65,79)(H,66,75)(H,67,80)(H,71,72)(H4,54,55,58)(H4,56,57,59)/t27-,30+,31+,32+,33+,34+,35+,36+,40+/m1/s1 InChIKey=YIANXWRCHNLVPZ-VXZNJSSOSA-N The active form is C-terminal amide group instead of C-terminal glycine residue. Peptide is the precursor of neuropeptide (ID 2897 in BIOPEP-UWM database of bioactive peptides). Reviews concerning C-terminal amidation of peptides: Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115 Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456
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